Because of its high concentration, essential oregano oil requires dilution in another carrier oil or liquid to make it safe, acceptable and suitable for use. Depending on the purpose for which the herbal remedy is used, the diluted oil may be applied topically, usually in a 1:1 ratio with olive oil or coconut oil. A liquid solution of oregano oil is drinkable when mixed with a glass of juice, using only a scant few drops of the essential oil, according to its intended use and instructions. There is also a capsulated form of oregano oil with a maximum dosage recommendation of 500 mg to 600 mg per day.

While oil of oregano is easily available through drugstores, to ensure the proper treatment and correct dosage, consulting a physician about the purposes and applications of oregano oil, before beginning treatment, is advisable. Maximum benefits can be achieved by using the best quality oil available, containing at least a 70 percent concentration of carvacrol.